有些女性在第一次性生活之后就出现尿频、尿急，甚至尿道口灼热等症状，这就是尿道综合征。这类患者通常尿道存在解剖结构的异常，尿道口离阴道口太近，在性生活时，阴道分泌物容易被挤压进入尿道口，这样一来，酸性的阴道分泌物刺激尿道，出现类似于化学性炎症反应，于是就有了尿频、尿急的症状。
另外，有的女性还有一异常结构，即有一块处女膜上翘，遮挡住尿道外口，医学上称之为“处女膜伞”，由于这把“伞”阻挡了尿液排出通道，当性生活时分泌物挤压入尿道或经期分泌物进入尿道后会滞留较长时间，排尿时就会形成一个旋涡，尿液也不能完全将这些分泌物冲刷干净，这样也会引起化学性炎症或感染而出现尿频、尿急，所以患者总觉得还有尿意。
由于生理解剖结构异常，所以需要手术矫正。第一，拉开尿道口与阴道的距离，减少阴道分泌物对尿道口的刺激。第二，切除处女膜伞，保证排尿时畅通无阻。
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