研究表明尿道综合征主要与以下原因有关：
1、泌尿系统感染：患者尿道口组织的病理改变均为慢性炎症反应。
2、尿道梗阻：如膀胱颈梗阻、尿道远端周围组织纤维化或括约肌痉挛导致远端尿道缩窄。
3、尿道外口解剖异常：如尿道处女膜融合、处女膜伞、小阴唇融合等。有报道，尿道外口至阴道口距离与尿道综合征关系密切，间距越近患病率越高，间距在3mm以下者患病率达72.15%。
4、神经功能异常：损伤、感染、X线照射等引起尿道内纤维组织增生，使神经发生异常反射。
5、心理因素：如紧张焦虑、多疑及内向等心理状态是尿道综合征的易感因素。
6、其他：如免疫因素、雌激素水平下降、镁离子缺乏、医源性因素等。
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