在绝经后的中老年妇女中，也有相当一部分出现女性尿道综合征。绝经后的妇女患此病主要是因为雌激素水平下降，使盆底肌肉逐渐萎缩、松弛，尿道向阴道方向内翻，括约肌松弛，而且尿道的抵抗力有所下降。
女性生育之后的两三年也是尿道综合征的高发期，这与生育之后性欲旺盛，性生活频繁有较大的关系，再加上分娩时，阴道扩张，阴道和尿道之间的组织被拉薄，阴道口和尿道口的距离变近了，所以，阴道分泌物容易入侵尿道，不断刺激尿道。如果加上卫生习惯不好，比如性生活之后不排尿、穿着过紧内裤等等，容易引起尿道腺体堵塞，出现尿频、尿急的反应。
在临床中还发现，不少已绝经的女性性生活还比较频繁，由于阴道的抵抗力下降，易受细菌感染而及尿道，引起尿道感染，尿常规检查结果常常会有白细胞异常升高的特点。
解决办法：绝经女性出现尿道综合征通常是雌激素水平下降引起的，在医生指导下补充植物性雌激素可以缓解症状。
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