预防尿道综合征要从生活各个方面着手，讲究会阴部的清洁卫生，防止会阴部接触脏东西，大便后最好用温水清洗肛门;有阴道炎及宫颈糜烂的要及时治疗;内衣裤最好是纯棉的，不要穿化纤的;洗外阴要用温开水，不要用过猛酸钾或肥皂水;平时多饮水，保持排尿通畅，防止尿液浓缩;小便后用干净柔软的纸擦净会阴;性生活的动作不要太大，结束后要用温开水洗净会阴。
在医生指导下服用小剂量的雌激素尼尔雌醇，每月服1次，每次服一片(5毫克)。另外，生活要规律，不吸烟不喝酒，多吃蔬菜水果，防止“生火”。
如果出现尿频、尿痛、零尿、尿道刺痒时，不要用手搔抓，要多用温开水洗几次会阴，或口服扑尔敏、氟美松。症状严重的，要请医生治疗。对于较敏感者或初次接受此项检查者，于术前15-30分钟给予镇静剂。
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